Forty-five minutes south of Charleston International Airport, The Sanctuary resort (from $275; 877-683-1234, at Kiawah Island is located on a secluded subtropical barrier isle that buffers the South Carolina coast and the Atlantic Ocean.

Heart-Healthy Fitness Kiawah Island offers 10 miles of uninterrupted white-sand beaches, five championship golf courses and tennis courts. You also can rent kayaks from local Heron Park Nature Center ($45 for two hours; 843-768-6001); keep your eyes peeled for dolphins, sea turtles and more than 220 bird varieties. Or dive into the warm Atlantic: The region's temperate climate makes swimming pleasant eight months out of the year.

R & R Snuggle up in a plush custom-crafted, four-poster bed fitted with luxuriant Italian linens or draw the drapes and swing open the doors to your own 40-square-foot balcony and watch the sun sink into the Atlantic's iridescent waves of blue. (All 255 rooms in the antebellum mansion-style hotel have one!)

Table for Two For dinner, reserve a table at the swanky Jasmine Porch, which serves up gourmet twists on Southern staples. Try the pan-seared grouper with Carolina Gold rice pilaf or the savory shrimp and grits (entrees $19-$36). But be sure to save room for dessert favorites like fresh peach cobbler ($8).

Spa-ing it After an invigorating day outdoors, unwind with the Spa at the Sanctuary's Signature Massage, in which your therapist applies "Body Wrapture" herbal heat wraps to key tension areas and major muscle groups (from $140 for 60 minutes; customized couples treatments available from $260).

*Prices (in U.S. dollars) are double occupancy and do not include taxes or transportation unless otherwise noted. Package details are subject to change.